Trimix is an accepted second-line drug for ED treatment when oral PDE5 inhibitors aren’t effective or cause side effects. Compared to PDE5 inhibitors like Viagra, Cialis, or Levitra, studies show Trimix is often more effective for patients with diabetes or those unresponsive to oral meds. Clinical trial results indicate patients using Trimix achieved erections firm enough for sex 82-90% of the time, versus 62-72% with PDE5 inhibitors alone. Trimix may also work faster since it is injected directly into the penis.